BILLIAN
INTERACTION THEORY
Bill
Adongo
Google Authorship
From Ghana, West Africa
The name Billian comes from my name Bill. The Billian Interaction Theory is form of mathematical hypothesis that
is used to hypothesize the behavior of enzymatic reactions. Billian Interaction Theory is not
limited to only hypothesizing the behavior of enzymes, but also used to describe
biochemical reactions such as antigen-antibody bind DNA-DNA hybridization, and protein-protein
interaction, etc.
In the matter of hypothesizing the relationship of reaction
rate v, to the maximum possible rate Vmax, the concentration substrate, [s], that is half the Billian
constant Bm. The
mathematical relationship is given as;
[s]=Bm/2
V=2Vmax[s]/Bm
The Vmax
represents the maximum possible rate, v represents the reaction rate rate, Bm represents the Billian
constant and and [s] represents the concentration substrate. In Billian Interaction Theory the reaction rate, must approach the maximum possible rate Vmax, indicating that the
parameters [s] and Bm is accurate.
Considered a reaction with S, and turns into ES with
rate constant kf which
turns into E and regenerates P with rate constant Kcat. ES can turn back into E
and P, with rate constant kr. The hypothesize is given
as;
The logic which the reaction rate approaches the maximum
possible rate and the Billian constant
is twice the concentration substrate has the Equations;
V=2Kcat[E]0[s]/Bm
V=2Kcat[E]0/2
Bm=2[s]
The parameter [E]0
from the equations above is enzyme concentration. Knowing Kr and Kf for substrate unbinding and binding to enzymes. The Billian constant can also hypothesize
as;
Bm=Kr/2Kf
CONCLUSION
Even though, German biochemist Leonor Michaelis, Canadian physician Maud Menten, British botanist G.E.
Briggs and British genereticest J.B.
Hadane has invented models that is used to hypothesize enzymatic reaction,
their limitations are accuracy and simplicity, Baillian interaction Theory covers all the limitations.
